?neuroendocrine

neuroendocrine發(fā)音

英：[nju:r?'end?kra?n]　　美：[?kra?n]

英：　　美：

neuroendocrine中文意思翻譯

adj. 神經(jīng)內(nèi)分泌的

neuroendocrine常見例句

1 、Abstract: The formation and mechanism of neuroendocrine differentiation ceils in partial breast cancers are not well elucidated yet.───文章摘要: 神經(jīng)內(nèi)分泌分化細(xì)胞存在于部分乳腺癌組織中，其形成機(jī)制尚未完全闡明。

2 、Keywords hypothalamus;supraoptic nucleus;neuroendocrine cell;intracellular recording;synaptic transmission;───下丘腦;視上核;神經(jīng)內(nèi)分泌細(xì)胞;細(xì)胞內(nèi)記錄;突觸傳遞;

3 、Influence of alternating magnetic field on neuroendocrine and its analgesic effect───交變磁場(chǎng)對(duì)神經(jīng)內(nèi)分泌活動(dòng)的影響與止痛效應(yīng)

4 、We report a case of 40-year-old man who has small cell neuroendocrine carcinoma of ethmoid sinus with invasion of upper aspect of right maxillary sinus and medial aspect of right orbit.───我們報(bào)告一位原發(fā)篩骨腔小細(xì)胞神經(jīng)內(nèi)分泌癌的案例，腫瘤侵犯至右眼窩內(nèi)側(cè)及上顎鼻竇腔；

5 、Under specific enviromental information,neuroendocrine cells produce and secrete diapause hormone(DH).───在特定的環(huán)境條件信息下 ,神經(jīng)分泌細(xì)胞產(chǎn)生和分泌滯育激素 (DH)。

6 、neuroendocrine breast carcinoma───乳腺神經(jīng)內(nèi)分泌癌

7 、Effects of Psycho-Behavioral Intervention on the Neuroendocrine Reactivity in Different Trait Anxiety Athletes after Stress───心理行為干預(yù)后不同特質(zhì)焦慮運(yùn)動(dòng)員應(yīng)激后的神經(jīng)內(nèi)分泌反應(yīng)

8 、Functional disease of the CNS with neuroendocrine disturbance───中樞神經(jīng)系統(tǒng)功能性疾病伴神經(jīng)內(nèi)分泌紊亂

9 、diffus neuroendocrine system───彌散性神經(jīng)內(nèi)分泌系統(tǒng)

10 、Abstract： Leptin is a kind of cytokine-like hormone produced by the adipocytes,which can play an important role in many physiological process such as energy metabolism,neuroendocrine and so on.───摘要： 瘦素是由脂肪細(xì)胞分泌的一種細(xì)胞因子樣激素，其在能量代謝、神經(jīng)內(nèi)分泌等多種生理過程中發(fā)揮重要作用。

11 、diffuse neuroendocrine system(DNES)───彌漫性神經(jīng)內(nèi)分泌系統(tǒng)

12 、The complex neuroendocrine control of GH release has been extensively reviewed [2,3].───復(fù)雜的神經(jīng)內(nèi)分泌控制的生長(zhǎng)激素釋放，也得到了廣泛檢討[ 2,3 ] 。

13 、Objective To analyse the clinical characteristics, therapeutic modalities and prognosis of pulmonary large cell neuroendocrine carcinoma (LCNEC).───摘要目的分析肺大細(xì)胞神經(jīng)內(nèi)分泌癌(LCNEC)臨床相關(guān)特點(diǎn)及治療、預(yù)后和影響預(yù)后的因素。

14 、Abstract : AIM: To study the effects and significance of amount, distribution and their secreting function of pulmonary neuroendocrine cells (PNECs ) following left cervical vagotomy in rats.───摘要 摘要：目的：觀察鼠左側(cè)迷走神經(jīng)切斷后肺神經(jīng)內(nèi)分泌細(xì)胞數(shù)量、分布及神經(jīng)活性物質(zhì)的分泌功能變化及其意義。

15 、Diffuse Neuroendocrine System Cells in Lymphoid Tissue of Succulus Rotundus of Rabbit───兔圓小囊淋巴組織中神經(jīng)內(nèi)分泌細(xì)胞

16 、Keywords Myoblastomatoid breast carcinoma;Histiocytoid breast carcinoma;Apocrine carcinoma;Responsive granuloma;Neuroendocrine differentiation.;───乳腺肌母細(xì)胞樣癌;乳腺組織細(xì)胞樣癌;大汗腺癌;反應(yīng)性肉芽腫;神經(jīng)內(nèi)分泌分化;

17 、Keywords exercise induced cardiac hypertrophy;neuroendocrine;pass way for signal transduction;gene expression;───關(guān)鍵詞運(yùn)動(dòng)性心肌肥大;神經(jīng)內(nèi)分泌;信號(hào)轉(zhuǎn)導(dǎo)通路;基因表達(dá);

18 、Effect of Ginseng and Aconite Root Infection on Neuroendocrine System and Cardiac Ventricle Remodelling of Heart Failure Patients───參附注射液對(duì)心力衰竭患者神經(jīng)內(nèi)分泌系統(tǒng)及心室重塑的影響

19 、Methods 2 cases of the neuroendocrine carcinoma of infratemporal space were analyzed and the samples were stained by immunohistochemistry.───方法對(duì)2例原發(fā)于顳下凹區(qū)的神經(jīng)內(nèi)分泌癌進(jìn)行臨床分析和總結(jié),對(duì)標(biāo)本行免疫組化染色。

20 、Study of neuroendocrine of rats with innate kidney deficiency syndrome induced by dread───先天恐懼的腎虛鼠的神經(jīng)內(nèi)分泌研究

21 、Neuroendocrine Regulation Mechanism on Gluconeogenesis and Fat Mobilization of Ketosis and Fatty Liver in Dairy Cows───奶牛酮病、脂肪肝糖異生和脂肪動(dòng)員的神經(jīng)內(nèi)分泌調(diào)控機(jī)制

22 、Objective: Insulinoma is the most common functional neuroendocrine tumor of the pancreas.───摘要胰島素瘤為胰臟最常見的神經(jīng)內(nèi)分泌瘤。

23 、In this review, we primarily focus on the behavioral-neuroendocrine mechanism of development of homosexuality from genetic, neuroendocrine neuroanatomical and behavioral studies.───摘要本文主要從生物學(xué)角度出發(fā)，從遺傳學(xué)、神經(jīng)內(nèi)分泌學(xué)、行為學(xué)和神經(jīng)解剖學(xué)方面綜述了同性戀發(fā)生的神經(jīng)內(nèi)分泌機(jī)制。

24 、Neuroendocrine regulation of thermogenesis of brown adipose tissue in the cold-exposed Brandt's voles───布氏田鼠在冷暴露條件下褐色脂肪組織產(chǎn)熱的神經(jīng)內(nèi)分泌調(diào)節(jié)

25 、Placental metastasis from a case of neuroendocrine small cell carcinoma of the uterine cervix complicating pregnancy───子宮頸神經(jīng)內(nèi)分泌小細(xì)胞癌**轉(zhuǎn)移的電鏡觀察

26 、There are lower serotonin function and neuroendocrine impairments in OCD patients,which supports the hypothesis of serotonin dysfunction in OCD.───強(qiáng)迫癥患者存在 5 HT能低下和神經(jīng)內(nèi)分泌功能的紊亂 ,強(qiáng)迫癥的 5 HT能假說能解釋其某些內(nèi)分泌功能紊亂。

27 、These three neuroendocrine tumors showed different histological morphological character and biological behavior. Immunohistochemically, 14,14,4 cases showed positive immunoreactions to NSE, Syn, CgA respectively.───免疫組織化學(xué)上 ,NSE** 14例 ,Syn** 14例 ,CgA** 4例。

28 、This paper reviewed the advance of g en etics,neurobiochemistry,neuroimmunology,neuroendocrine,neuroe lectrophysiolo gy,neuroscreenage in major depression and anxiety disorder.───文章就抑郁癥和焦慮癥在遺傳學(xué)、神經(jīng)生化學(xué)、神經(jīng)免疫學(xué)、神經(jīng)內(nèi)分泌學(xué)、神經(jīng)電生理學(xué)、神經(jīng)影像學(xué)方面的研究進(jìn)展作一綜述。

29 、Thymic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1: A Comparative Study on 21 Cases Among a Series of 761 MEN1 from the GTE (Groupe des Tumeurs Endocrines).───多發(fā)性內(nèi)分泌腺瘤1型患者出現(xiàn)的胸腺神經(jīng)內(nèi)分泌腫瘤：來自GTE的761例MEN1患者中21例胸腺神經(jīng)內(nèi)分泌腫瘤的對(duì)比研究。

30 、The Association between Neuroendocrine Differentiation in Carcinoma of the Mammary and its Prognosis───乳腺癌伴神經(jīng)內(nèi)分泌分化及與預(yù)后的關(guān)系

31 、Expression of NSE, CgA and Syn in neuroendocrine tumors───NSE,CgA,Syn在神經(jīng)內(nèi)分泌腫瘤診斷中的應(yīng)用

32 、Relationship Among Interventional Therapy with Neuroendocrine System and Fibrinolytic System───介入治療與神經(jīng)內(nèi)分泌及纖溶狀態(tài)的關(guān)系

33 、Keywords RET gene;PHOX2B gene;Hirschsprung's disease;polymorphism;haplotype;neuronal intestinal dysplasia;pathology;enterocolitis;immunohistochemistry;neuroendocrine vesicle;───先天性巨結(jié)腸;單核苷酸多態(tài)性;RET基因;PHOX2B基因;單倍型;腸神經(jīng)元發(fā)育不良;病理;小腸結(jié)腸炎;免疫組化;神經(jīng)內(nèi)分泌囊泡;

34 、Effects of bioactive compounds from entomogenous fungi on neuroendocrine in depression rat models───新型蟲生菌提取物對(duì)慢性應(yīng)激抑郁大鼠神經(jīng)內(nèi)分泌的影響

35 、Action potential (AP) is a very important physiological signal in excitable cells including neurons and neuroendocrine cells.───動(dòng)作電位，對(duì)于可興奮細(xì)胞，包括神經(jīng)元和一些內(nèi)分泌細(xì)胞，是一種非常重要的生理信號(hào)。

36 、Apart from its effect on the pituitary,it has been suggested that CRH acts within the central nervous system(CNS) and influence a number of behavioral,neuroendocrine,and autonomic responses to stress.───CRH除對(duì)垂體腺的影響外，在中樞神經(jīng)系統(tǒng)（central nervous system ，CNS）中CRH可影響應(yīng)激導(dǎo)致的行為、神經(jīng)內(nèi)分泌、自發(fā)反應(yīng)等。

37 、Imaging appearances of primary hepatic and gallbladder neuroendocrine carcinomas───原發(fā)性肝、膽囊神經(jīng)內(nèi)分泌癌的影像學(xué)表現(xiàn)

38 、EFFECT OF NEUROENDOCRINE CELL ON HUMAN FETAL LUNG───人胎肺神經(jīng)內(nèi)分泌細(xì)胞的發(fā)育及其作用

39 、Abstract： Objective To study differentiation of neuroendocrine (NE) in non-small cell lung carcinoma (NSCLC) and its effect on the responsiveness to chemotherapy.───摘 要： 目的為研究非小細(xì)胞肺癌的神經(jīng)內(nèi)分泌分化狀況及其對(duì)化療療效的影響。

40 、In this study we hae ealuated the efficacy of Remifentanil in controlling haemodynamic and some neuroendocrine responses to tracheal intubation in smokers compared with non-smokers.───在這個(gè)研究中我們?cè)u(píng)價(jià)了瑞芬太尼在控制氣管**管引起的血流動(dòng)力學(xué)和神經(jīng)內(nèi)分泌反應(yīng)方面吸煙者和非吸煙者的差別。

41 、The center neuroendocrine mechanism study for the impact of experimental stress on plasma glucose level in Chinese Hamster───實(shí)驗(yàn)性應(yīng)激對(duì)中國地鼠血糖增高的中樞神經(jīng)內(nèi)分泌機(jī)制研究

42 、We report a case of high grade large cell neuroendocrine carcinoma concomitant with tubulovillous adenoma of the ampulla of Vater.───摘要本文報(bào)告一個(gè)壺腹部高級(jí)大細(xì)胞型神經(jīng)內(nèi)分泌癌并生絨毛管狀腺瘤的病例。

43 、Proenkephalin has been found in various invertebrates tissues, especially immune and neuroendocrine systems.And it has been reported to attend various immune regulation mechanism.───摘要腦啡肽原在無脊椎動(dòng)物免疫神經(jīng)等器官系統(tǒng)廣泛存在，并參與諸多免疫調(diào)節(jié)機(jī)制。

44 、COMPARATIVE STUDY ON THE DISTRIBUTION AND MORPHOLOGY OF NEUROENDOCRINE CELLS IN HUMAN AND RAT ANTRAL MUCOSA───人和大鼠胃竇部神經(jīng)內(nèi)分泌細(xì)胞分布和形態(tài)學(xué)的比較研究

45 、Classical hypothalamic-pituitary-adrenal （HPA） axis is a negative feedback neuroendocrine system which is essential for the rapid response of organisms to external or internal stress.───下丘腦-垂體-腎上腺皮質(zhì)軸是生物體對(duì)體內(nèi)外各種應(yīng)激刺激做出快速反應(yīng)所必需的神經(jīng)內(nèi)分泌負(fù)反饋調(diào)節(jié)系統(tǒng)。

46 、Experimental research of herbal formula-gengniankang delaying aging process of neuroendocrine system in aged female rats with osteoporosis───復(fù)方更年康延緩老年骨質(zhì)疏松雌性大鼠神經(jīng)內(nèi)分泌衰老的實(shí)驗(yàn)研究

47 、Keywords dairy cows;hypoglycemia;ketosis;fatty liver;quantitive RT-PCR;calf hepatocyte and adipocyte culture in vitro;neuroendocrine factors;───奶牛;低血糖;酮病;脂肪肝;定量RT-PCR;犢牛肝細(xì)胞和脂肪細(xì)胞;體外培養(yǎng);神經(jīng)內(nèi)分泌因子;

48 、Outline of Diffuse Neuroendocrine System───彌散神經(jīng)內(nèi)分泌系統(tǒng)研究概論

49 、"The effect on the ANS and neuroendocrine function in turn affects the signals to the heart, leading to cardiac instability.───外界因素是先影響到自主神經(jīng)系統(tǒng)以及神經(jīng)內(nèi)分泌系統(tǒng)，這兩者變化才進(jìn)一步傳遞信號(hào)給心臟，導(dǎo)致心臟的不穩(wěn)定性?！?/p>

50 、Keywords Xinlishu naristillae;Chronic heart failure;Neuroendocrine cytokines;Rats;───心力舒滴鼻劑;慢性心力衰竭;神經(jīng)內(nèi)分泌細(xì)胞因子;大鼠;

51 、Keywords congenital heart disease;congestive heart failure;neuroendocrine disorder;───先天性心臟病;心力衰竭;神經(jīng)內(nèi)分泌紊亂;

52 、In treating asthma,this therapy functions to suppress allergy,regulate neuroendocrine,reduce airway hyperresponsiveness,improve lung functions and regulate immunity.───據(jù)研究,補(bǔ)腎治喘的機(jī)理主要在于:抑制變態(tài)反應(yīng);調(diào)整神經(jīng)內(nèi)分泌功能;降低高氣道反應(yīng)性;改善肺功能;調(diào)節(jié)免疫作用。

53 、Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia───彌漫性特發(fā)性肺神經(jīng)內(nèi)分泌細(xì)胞增生

54 、Characteristics and neuroendocrine mechanisms of adult diapause───成蟲滯育的主要特點(diǎn)及神經(jīng)內(nèi)分泌調(diào)控

55 、alterations in immune system actiation, central nerous system dysregulation, impaired nere conduction, and neuroendocrine dysregulation hae to be considered.───免疫系統(tǒng)激活變化、中樞神經(jīng)系統(tǒng)失調(diào)、神經(jīng)傳導(dǎo)受損和神經(jīng)內(nèi)分泌失調(diào)均被考慮過。

56 、When severe hypokalemia is coupled with pain, which can not only induce neuroendocrine stress response but also cause arrhythmias, the impact should not be overlooked because aggravated arrhythmia may ensue.───在嚴(yán)重低血鉀的情形下，若再加上本來就足以引起神經(jīng)內(nèi)分泌壓力反應(yīng)與心律不整的疼痛，可能會(huì)造成更嚴(yán)重的心律不整，其影響不容忽視。

57 、Keywords Ovarian neoplasm;Struma carcinoid;Neuroendocrine neoplasm;Immunohistochemisty;───卵巢腫瘤;甲狀腺腫;類癌;免疫組化染色;

58 、Thymic neuroendocrine carcinoma───臨床病理特征

59 、Small cell lung cancer is neuroendocrine neoplasm and origins from APUD (amine precursor uptake decarboxylation)cell.───小細(xì)胞肺癌是神經(jīng)內(nèi)分泌腫瘤,起源于APUD(胺前體攝取脫羧化)細(xì)胞。

60 、We report a case of well-differentiated mucinous neuroendocrine carcinoma in an aged woman who presented with a right breast lump.───摘要本文報(bào)告一位75歲女性患者，在她右側(cè)乳房長(zhǎng)出一個(gè)黏液性神經(jīng)與內(nèi)分泌癌。

61 、Therefore, CRES may perform unique and tissue specific functions in the reproductive and neuroendocrine systems.───因此 ,CERS在生殖系統(tǒng)和神經(jīng)內(nèi)分泌系統(tǒng)中的功能也許是獨(dú)特的和組織特異性的。

62 、Keywords Congestive heart failure;neuroendocrine hormone;Profiting Qi;Warming Yang and Promoting Blood Circulation;───關(guān)鍵詞充血性心力衰竭;神經(jīng)內(nèi)分泌激素;益氣溫陽活血法;

63 、Variation of ventricular remodeling, the changes of endocrine hormone and the role of the neuroendocrine antagonist in patients with myocardial infarction───心肌梗死患者心室重構(gòu)演變及內(nèi)分泌激素變化與神經(jīng)內(nèi)分泌拮抗劑的作用

64 、Effect of Octacosanol on the Behavior and Neuroendocrine Index of Rat Forced by Cold Water Swimming───二十八烷醇對(duì)強(qiáng)制冷水應(yīng)激大鼠行為及神經(jīng)內(nèi)分泌指標(biāo)的影響

65 、Keywords Non-small cell lung cancer Neuroendocrine Survival;───關(guān)鍵詞非小細(xì)胞肺癌;神經(jīng)內(nèi)分泌;生存;

66 、To explore the effect of substance P (SP) in Paraventricular nucleus (PVN) in rats on the asthma onset and its possible mechanism in neuroendocrine.───探討哮喘大鼠下丘腦室旁核(PVN)內(nèi)P物質(zhì)(SP)在哮喘發(fā)病中的神經(jīng)內(nèi)分泌調(diào)制作用。

67 、Small cell neuroendocrine carcinoma is often seen in the lung but rarely in the head and neck region.───摘要小細(xì)胞神經(jīng)內(nèi)分泌癌最常發(fā)生在肺部，發(fā)生在頭頸部者非常少見；

68 、Two important differential diagnoses exist in this direction - metastatic melanoma and metastatic small cell (or neuroendocrine) carcinoma.───兩種重要的鑒別診斷是：轉(zhuǎn)移性黑色素瘤和轉(zhuǎn)移性小細(xì)胞（或神經(jīng)內(nèi)分泌）癌。

69 、dispersed neuroendocrine cell system───彌散的神經(jīng)內(nèi)分泌細(xì)胞系統(tǒng)

70 、Changes of neuroendocrine factor and cardiac index after interventional therapy───介入治療房間隔缺損后神經(jīng)內(nèi)分泌因子及心指數(shù)的變化

71 、diffuse neuroendocrine system───彌漫的神經(jīng)內(nèi)分泌系統(tǒng)

72 、Keywords fetal;thymus;diffuse neuroendocrine system;chromogranin A;neuron specific enolase;somatostatin;vasoactive intestinal peptide;───關(guān)鍵詞胎兒;胸腺;彌散神經(jīng)內(nèi)分泌系統(tǒng);嗜鉻素A;神經(jīng)元特異性烯醇化酶;生長(zhǎng)抑素;血管活性腸肽;

73 、The coexistance of NO and AVP may play important role in the regulation of endocrine and neuroendocrine by the magnetic field.───一氧化氮和血管加壓素的共存可能對(duì)磁場(chǎng)調(diào)節(jié)內(nèi)分泌具有一定意義。

74 、Large cell neuroendocrine carcinoma (LCNEC) is a poorly differentiated high-grade neuroendocrine tumor with very aggressive behavior.───摘要大細(xì)胞神經(jīng)分泌性癌是一種分化不良、高度的神經(jīng)內(nèi)分泌癌且癌性相當(dāng)惡性。

75 、Effects of acute and chronic restraint stress on visceral sensitivity and neuroendocrine response in rats───急性和慢性束縛應(yīng)激對(duì)大鼠內(nèi)臟敏感性和神經(jīng)內(nèi)分泌的影響

76 、Abstract: Corticortropin-releasing hormone (CRH) is an important hormone in neuroendocrine system, which plays a wide role in central nervous system and its mechanisms are complicated.───促腎上腺皮質(zhì)激素釋放激素(CRH)是神經(jīng)內(nèi)分泌系統(tǒng)的重要激素,其中樞作用廣泛且作用機(jī)制復(fù)雜。

77 、Objective: To study the diagonosis, patholgical characteristics and treatment of gastrointestinal neuroendocrine carcinoma(GNEC).───摘要目的：探討胃腸道神經(jīng)內(nèi)分泌癌的臨床診斷、病理學(xué)特點(diǎn)和治療。

78 、Patients in the study had advanced pancreatic islet cell tumors, also known as neuroendocrine cancer.───參與研究的患者患有晚期胰島細(xì)胞瘤（也稱為神經(jīng)內(nèi)分泌瘤）。

79 、Keywords dairy cows;DMI;performance;fat mobilization;neuroendocrine regulation;triglyceride lipase;gene expression;───奶牛;干物質(zhì);瘦蛋白;脂肪動(dòng)員;激素敏感脂酶;基因表達(dá);

80 、Effects of Compound Zhenwu Granule on Neuroendocrine in Rabbits with Experimental Heart Failure───復(fù)方真武沖劑對(duì)心力衰竭家兔神經(jīng)內(nèi)分泌的影響

直腸神經(jīng)內(nèi)分泌腫瘤是癌嗎？

直腸神經(jīng)內(nèi)分泌腫瘤是癌嗎

直腸神經(jīng)內(nèi)分泌腫瘤不全是癌，但都屬于惡性腫瘤。

神經(jīng)內(nèi)分泌腫瘤是起源于神經(jīng)內(nèi)分泌細(xì)胞的腫瘤，可以發(fā)生在體內(nèi)任何部位，最常見的是胃、腸、胰腺等消化系統(tǒng)，約占所有神經(jīng)內(nèi)分泌腫瘤的2/3左右。根據(jù)WHO2010年對(duì)神經(jīng)內(nèi)分泌腫瘤的最新命名規(guī)定，以“Neuroendocrine neoplasm（NEN）”泛指所有源自神經(jīng)內(nèi)分泌細(xì)胞的腫瘤，其中高分化的腫瘤命名為神經(jīng)內(nèi)分泌瘤（neuroendocrine tumor，NET），低分化的腫瘤命名為神經(jīng)內(nèi)分泌癌（neuroendocrine carcinoma，NEC）。 按照腫瘤的增殖活性，又將其分為G1（低級(jí)別）、G2（中級(jí)別）、G3（高級(jí)別）3個(gè)級(jí)別，級(jí)別越高，惡性程度越高。分化差的神經(jīng)內(nèi)分泌癌生存期只有約10個(gè)月，分化好神經(jīng)內(nèi)分泌瘤的進(jìn)展相對(duì)緩慢，生存期從3年到20年不等。

因此，直腸神經(jīng)內(nèi)分泌腫瘤患者的隨訪與復(fù)查需要與醫(yī)生密切溝通，根據(jù)腫瘤大小、部位、分級(jí)與分期等具體情況采取不同的方案。

本內(nèi)容由中國醫(yī)學(xué)科學(xué)院腫瘤醫(yī)院 腫瘤內(nèi)科 副主任醫(yī)師 宋巖審核

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喬布斯為什么會(huì)得胰腺神經(jīng)內(nèi)分泌瘤？這種腫瘤貌似并不常見？

很多人一發(fā)現(xiàn)胰腺里有腫瘤，就以為是胰腺癌。當(dāng)年蘋果教父喬布斯的離開不少人認(rèn)為是因?yàn)橐认侔?，而真正帶走喬布斯的其?shí)是胰腺神經(jīng)內(nèi)分泌瘤！

胰腺神經(jīng)內(nèi)分泌腫瘤≠胰腺癌

事實(shí)上，不是所有長(zhǎng)在胰腺上的腫瘤都叫胰腺癌。胰腺神經(jīng)內(nèi)分泌腫瘤和胰腺癌，雖然都是“生長(zhǎng)”在胰腺位置，但它們?cè)诎l(fā)病情況、致病機(jī)理、治療方式、預(yù)后生存等方面存在著天壤之別。

胰腺神經(jīng)內(nèi)分泌腫瘤的惡性程度遠(yuǎn)沒有胰腺癌“兇險(xiǎn)”。

胰腺癌是名符其實(shí)的癌中之王，5年的生存率僅為5％，晚期胰腺癌的中位生存時(shí)間僅有3-6個(gè)月。

對(duì)比而言胰腺神經(jīng)內(nèi)分泌腫瘤的生存情況要樂觀的多，早期患者手術(shù)后的10年的生存率可達(dá)到100％，即使晚期的胰腺神經(jīng)內(nèi)分泌腫瘤患者的5年生存率也能達(dá)到25-40%。

眾所周知的蘋果前CEO喬布斯就是患的胰腺神經(jīng)內(nèi)分泌腫瘤。

許多媒體將喬布斯的腫瘤稱為“胰腺癌”，但要知道喬布斯于2003年確診，2004年才接受手術(shù)治療，并在確診后生存了8年，而胰腺癌的5年的生存率僅為5％，他能與“癌中之王” —胰腺癌抗?fàn)庨L(zhǎng)達(dá)8年嗎？

真相是喬布斯所患的并非胰腺癌，而是神經(jīng)內(nèi)分泌腫瘤。胰腺神經(jīng)內(nèi)分泌腫瘤遠(yuǎn)不如胰腺癌“強(qiáng)大”，才是喬布斯能夠長(zhǎng)期抗?fàn)幍恼嬲颉?/p>

什么是胰腺神經(jīng)內(nèi)分泌腫瘤？

胰腺神經(jīng)內(nèi)分泌腫瘤（pancreatic neuroendocrine tumors ,pNETs）是一類起源于胰腺神經(jīng)內(nèi)分泌細(xì)胞較罕見的異質(zhì)性胰腺腫瘤,大多數(shù)為散發(fā)性,病因和具體發(fā)病機(jī)制尚不明確,近年發(fā)病率逐漸上升。

胰腺神經(jīng)內(nèi)分泌腫瘤根據(jù)是否伴有全身性內(nèi)分泌癥狀可分為功能性和非功能性兩類。

多數(shù)pNETs為非功能性

約占70-80%，臨床上大部分患者是沒有癥狀的，患者多數(shù)是在體檢時(shí)才發(fā)現(xiàn)胰腺上長(zhǎng)了個(gè)腫瘤，比如本文中所講到魏老太病例；

功能性的pNETs會(huì)分泌一些激素

因此會(huì)產(chǎn)生特殊的臨床癥狀：

1.比如有的胰腺神經(jīng)內(nèi)分泌腫瘤會(huì)分泌大量的胰島素，表現(xiàn)為低血糖癥狀；

2.有的胰腺神經(jīng)內(nèi)分泌腫瘤會(huì)分泌大量的胰高血糖素，表現(xiàn)為高血糖、腹瀉等癥狀；

3.而有的胰腺神經(jīng)內(nèi)分泌腫瘤會(huì)分泌大量的胃泌素，表現(xiàn)為腹痛、胃潰瘍等癥狀。

4.肝臟是神經(jīng)內(nèi)分泌腫瘤最常見的轉(zhuǎn)移部位。

胰腺腫瘤應(yīng)首選CT或MR增強(qiáng)檢查

胰腺CT薄層增強(qiáng)掃描，對(duì)于腫瘤**、與鄰近臟器、血管之間關(guān)系的判定更加準(zhǔn)確；

而MR增強(qiáng)掃描對(duì)于不同胰腺腫瘤的成分鑒別更有優(yōu)勢(shì)，兩種檢查相輔相成，各有其價(jià)值。

核醫(yī)學(xué)診斷技術(shù)：PET/CT、PET/MR

PET/CT：可反應(yīng)病灶代謝情況，對(duì)于病灶良惡性的判斷以及對(duì)于全身其他隱匿轉(zhuǎn)移灶的檢出均具有良好的臨床應(yīng)用價(jià)值，進(jìn)而幫助臨床評(píng)估治療后療效。

PET/MR: 一體化PET/MR較PET/CT而言，具備了更高的敏感度，均有更高的的軟組織分辨率，極大提高早期、微小病變的診斷和監(jiān)測(cè)能力，進(jìn)而實(shí)現(xiàn)疾病在分子水平的診斷。

景哥提醒：

胰腺神經(jīng)內(nèi)分泌腫瘤大部分可無臨床癥狀，要想早期發(fā)現(xiàn)關(guān)鍵還在于定期體檢。

定期體檢，選擇合適的檢查項(xiàng)目，可以及早發(fā)現(xiàn)微小的腫瘤病灶，面對(duì)癌癥，早期治療才能提高生活質(zhì)量，延長(zhǎng)壽命。

如若不幸查出胰腺神經(jīng)內(nèi)分泌腫瘤時(shí)，也不要過于絕望，早期神經(jīng)內(nèi)分泌腫瘤經(jīng)手術(shù)治療后可預(yù)后良好。