?epitope

epitope發(fā)音

英：['ep?t??p]　　美：['ep??to?p]

英：　　美：

epitope中文意思翻譯

n. 抗原決定部位, 抗原決定基

epitope詞形變化

動(dòng)詞過(guò)去分詞: epitomized | 動(dòng)詞第三人稱(chēng)單數(shù): epitomizes | 動(dòng)詞過(guò)去式: epitomized | 動(dòng)詞現(xiàn)在分詞: epitomizing |

epitope常見(jiàn)例句

1 、Construction and Evaluation of HCV-NS3 Th1 Epitope Vaccine Based on Invariant Chain CLIP Substitution───基于Ii分子的HCV-NS3 Th1表位基因疫苗的設(shè)計(jì)及功能研究

2 、The Recombinant Fusion Protein of CTB and HCV Epitope: Antigenicity and Application to Anti-HCV ELISA Kit───CTB與HCV抗原決定簇融合蛋白的抗原性及其在抗HCV ELISA試劑盒中的應(yīng)用

3 、In 12 patients, the neutralizing antibodies recognized only a conformational epitope requiring proper folding of the epoetin protein.───在所有的患者中。

4 、The expression of human thyroid peroxidase epitope gene in Escherichia coli and its clinical assay application───人甲狀腺過(guò)氧化物酶抗原決定簇基因在大腸桿菌的表達(dá)及臨床測(cè)定應(yīng)用

5 、Keywords Epitope;Epidemiology;Peptide library;Phage;Thioredoxin;Surface display;───關(guān)鍵詞表位;流行病學(xué);肽庫(kù);噬菌體;硫氧還蛋白;表面展示;

6 、INFLUENCE OF DIFFERENT HEAT-INDUCED EPITOPE RETRIEVAL METHODS ON ENDOGENOUS BIOTIN IN HEPATOCELLULAR CARCINOMA TISSUES───不同抗原修復(fù)方法對(duì)肝癌組織中內(nèi)源性生物素的影響及對(duì)策

7 、Keywords SARS - CoV;spike protein;epitope;chimeric antigen gene;genetic engineering vaccine;───關(guān)鍵詞SARS冠狀病毒;S蛋白;抗原表位;嵌合抗原基因;基因工程疫苗;

8 、multi - epitope chimeric antigen───TpN47

9 、conformarion-dependent epitope───依賴(lài)(于)構(gòu)象的表位

10 、The method based on expressed peptide for mapping epitope on viral prot...───實(shí)驗(yàn)表明,用基因工程表達(dá)的多肽篩選抗原表位的方法是可行的。

11 、MAGE-3271-279 epitope peptide───MAGE-3271-279抗原肽

12 、Screening of a NMDA Receptor Epitope From Random Phage Display Peptide Library───噬菌體肽庫(kù)中篩選NMDA受體抗原表位

13 、Analysis of the death epitope in human Fas antigen───人Fas抗原死亡表位分析

14 、Analysis of a MAGE epitope recently found in a hepatocellular cell line on mRNA level───人肝癌細(xì)胞中一個(gè)MAGE抗原表位的獲得及mRNA水平分析

15 、Keywords human xylosyltransferase-I（XT-I）;antibody;epitope;───人木糖基轉(zhuǎn)移酶;抗體;抗原表位;

16 、Study on screening mimicking epitope of ochratoxin A from phage display peptide library───噬菌體展示肽庫(kù)篩選赭曲霉毒素A模擬表位的研究

17 、Keywords HPV;capsid protein L1;common epitope;immunity;───關(guān)鍵詞人乳頭瘤病毒;外殼蛋白L1;共同表位;免疫;

18 、As the protein comes off the ribosome, the protease immediately cuts itself and the epitope tag off, leaving the host protein unmarked.───在這個(gè)蛋白質(zhì)剛離開(kāi)核糖體的時(shí)候，蛋白酶馬上就自我切割，把表位標(biāo)記也切掉，結(jié)果讓寄主蛋白質(zhì)上沒(méi)有任何標(biāo)記。

19 、Keywords CTB;HBsAg epitope a;Fusion protein;ELISA;───**病毒表面抗原a表位;融合蛋白;ELISA;

20 、Specific Killing Effect against Homo-leukemia Hybrid Cell Induced by a Multiple Epitope BCR-ABL Fusion Protein───BCR-ABL融合抗原誘導(dǎo)特異性同源白血病融合細(xì)胞殺傷效應(yīng)研究

21 、Identification of Epitope Recognized by Monoclonal Antibody with Phage-displayed Random Peptide Library───噬菌體隨機(jī)肽庫(kù)在確定單抗識(shí)別表位中的應(yīng)用

22 、Keywords phage display peptide library;mimicking epitope;ochratoxin A;monoclonal antibody;immunoassay;───噬菌體展示肽庫(kù);赭曲霉毒素A;模擬表位;單克隆抗體;免疫分析;

23 、Keywords SSX tumor gene;epitope prediction;HLA-A2.1 restriction;combining affinity;───關(guān)鍵詞SSX腫瘤基因;表位預(yù)測(cè);HLA-A2.1限制性;結(jié)合親和力;

24 、CLONE AND EXPRESSION OF HUMAN PAPILLOMAVIRUS TYPE 16 L2 OPEN READING FRAME ENCODED EPITOPE───HPV16L2開(kāi)放讀碼框編碼表位的基因克隆和表達(dá)

25 、Keywords GST fusion-expression;hepatitis E virus;monoclonal antibody;antigenic epitope;───GST融合表達(dá);戊型肝炎病毒;單克隆抗體;抗原表位;

26 、The aboe-mentioned CTL epitope prediction results exist certain deiation, due to difference of their database source of building matrix motifs ...───上述這些CTL表位預(yù)測(cè)程序,依據(jù)其建立矩陣的數(shù)據(jù)來(lái)源和打分函數(shù)形式的不同,預(yù)測(cè)結(jié)果也會(huì)有一定偏差。

27 、Keywords T lymphocyte;LMP2 mixed peptide;dentritic cell;EBV infection;PBMNC;EBV epitop;───LMP2混合肽;樹(shù)突狀細(xì)胞;EB病毒感染;外周血單個(gè)核細(xì)胞;EB病毒抗原;T淋巴細(xì)胞;

28 、Keywords phage-displayed random peptide library;monoclonalantibody;epitope;NMDA receptor;───噬菌體隨機(jī)肽庫(kù);單克隆抗體;表位;NMDA受體;

29 、Keywords phage-displayed random peptide library;antigen epitope;HCV;───噬菌體隨機(jī)肽庫(kù);抗原表位;丙型肝炎病毒;

30 、Peptide of HBV surface antigen epitope───乙型肝炎表面抗原表位肽

31 、Neutralization antigenic epitope───中和抗原表位

32 、To identify native epitope of N protein, we constructed the ORF7 gene-targeted peptide library and screened by the MAb N3H2. After 3 rounds of biopanning, 3 clones were obtained.───為進(jìn)一步研究表位結(jié)構(gòu),本研究構(gòu)建了PRRSV ORF7基因特異性肽庫(kù),利用N3H2進(jìn)行了3輪篩選,獲得3個(gè)**噬菌體克隆.

33 、Keywords SARS-CoV;epitope;phage peptide library;───SARS冠狀病毒;表位;噬菌體肽庫(kù);

34 、The former population is derived from T1A progenitor cells that express Ran-2 epitope, whereas the later population and oligodendrocytes ( OL ) derived from bipotential O-2A progenitor cells that express A2B5 epitope.───兩型星形膠質(zhì)細(xì)胞分別由兩種不同抗原表達(dá)的祖細(xì)胞發(fā)育分化而來(lái)：T1A起源于抗原表型為Ran-2~+，A2B5~-的T1A前體細(xì)胞；

35 、Epitope mapping of scolex antigen of cystic echinococcosis from a 7 peptide phage library by using immobilized specific monoclonal antibody───噬菌體7肽庫(kù)中篩選細(xì)粒棘球蚴頭節(jié)抗原的模擬表位的初步研究

36 、Progress in the Studies of Protein B-Cell Epitope───B細(xì)胞蛋白質(zhì)抗原表位的研究方法進(jìn)展

37 、Expression and immunogenic analysis for the tandem-arranged multiple mimic epitope gene of Infectious Bursal Disease Virus───傳染性法氏囊病病毒多表位模擬肽串聯(lián)基因的表達(dá)與免疫原性分析

38 、Identification of peptide sequence and three dimensional structure of a epitope of cyclophilin A───親環(huán)素A抗原表位氨基酸序列及三維結(jié)構(gòu)研究

39 、Study on Peptide Mimicking Epitope of Adenovirus by Phage Peptide Library───噬菌體展示短肽模擬腺病毒表位的研究

40 、Epitope mapping of SAK by gene-targeted random fragment library───利用目的基因隨機(jī)表位庫(kù)篩選葡激酶抗原決定簇

41 、The binding to NP of the phage Fab could beinhibited by mouse niAb 1A8 when testing with inhibition ELISA, it indicatedthat they could bind the same epitope.───同時(shí) ELISA阻斷試驗(yàn)結(jié)果也表明鼠源性 mAb AS可明顯阻斷噬菌體表面表達(dá)的Fab與NP抗原的結(jié)合，表明鼠/人嵌合Fab抗體與IllilbIAS識(shí)別相同的抗原結(jié)合位點(diǎn)。

42 、Keywords hypervariable region 1 of hepatitis C virus mimic epitope antibody response;───丙型肝炎病毒高變區(qū)1;模擬表位;血清反應(yīng)性;

43 、Study of immunological characteristics of mimic epitope peptides displaying on the phage surface───噬菌體展示肽表位的免疫原性研究

44 、neutralizing epitope of JE virus E protein───乙腦病毒E蛋白中和表位

45 、Conclusion: DsbA-G1F/M2, the fusion protein of a CTL epitope and G protein fragment G1 can induce both cellular immunity and humoral immunity.───二者均誘導(dǎo)了高滴度的中和抗體,但與DsbA-G1相比,DsbA-G1F/M2所誘導(dǎo)的中和抗體滴度有所減弱。

46 、Keywords HIV envelope protein GP41;gene expression;immunodominant epitope;viral envelope proteins;───HIV包膜蛋白質(zhì)GP41;基因表達(dá);免疫優(yōu)勢(shì)表位;病毒融合蛋白質(zhì)類(lèi);

47 、conformation-independent epitope───不依賴(lài)(于)構(gòu)象的表位

48 、Keywords FMDV;FMD edible plant-based vaccine;Stylosanthes spp;ploy-antibody;antigen epitope;───口蹄疫病毒;口蹄疫植物可飼疫苗;柱花草;多克隆抗體;抗原表位;

49 、Our results suggest that MBP and PLP might play some important role in initiating demyelinating diseases, and that M87-106, P40-60, P95-117 and P185-206 might be candidates for antigen epitope relevant to MS.───作為神經(jīng)髓鞘主要成分的 MBP和 PLP免疫反應(yīng)性高 ,可能在體內(nèi)觸發(fā)自身免疫反應(yīng)過(guò)程發(fā)揮作用 ,而 M87-1 0 6、P40 -60、P95 -1 1 7和 P1 85 -2 0 6等位點(diǎn)值得進(jìn)一步研究。

50 、Selection of an antigen epitope recognized by anti-chlamydia monoclonal antibody with phage display peptide library───從噬菌體表面展示肽庫(kù)中篩選衣原體單克隆抗體識(shí)別的抗原表位

51 、To study character of the NDV-F protein epitope in the animal immune response,we cloned and expressed a gene fragment of NDV-F partial protein,and examined its immune reactivity.───為研究NDV-F蛋白抗原表位在動(dòng)物免疫應(yīng)答中的作用特點(diǎn),作者克隆和表達(dá)了NDV-F蛋白基因的部分片段,并檢測(cè)其免疫反應(yīng)性。

52 、the main antigen epitope gene───主要抗原表位基因

53 、DNA sequence of T-helper epitope───Th表位DNA序列

54 、Screening, Action Mechanism and Adjuvanticity with T Cell Epitope Peptide Specific for SARS-CoV of Immunopotentiators───免疫增強(qiáng)劑的篩選和作用機(jī)理研究及其對(duì)嚴(yán)重急性呼吸綜合癥冠狀病毒（SARS-CoV）表位多肽佐劑作用的初步研究

55 、A monoclonal antibody binds to G-actin but not to F-actin. What does this tell you about the epitope recognized by the antibody?───一個(gè)單克隆抗體能與G-actin結(jié)合但不與F-actin結(jié)合，這告訴你這個(gè)抗體識(shí)別的半抗原的什么情況?

56 、Some non-NPC neoplasms being demonstrated BAE-5 positivity may be due to the presence of EBV EA-R antigenic epitope or polypeptides simulating the structure of EA-R.───一些非鼻咽癌腫瘤能與BAE-5起**反應(yīng),可能是由于這些腫瘤細(xì)胞中也有EB病毒早期抗原存在或者可能存在與EA-R抗原決定簇相類(lèi)似結(jié)構(gòu)的多肽而引起交叉反應(yīng)。

57 、Prediction of the Secondary Structure and B-Cell Epitope of Human Mast Cell Chymase───人肥大細(xì)胞類(lèi)糜蛋白酶序列結(jié)構(gòu)分析及B細(xì)胞表位預(yù)測(cè)

58 、Keywords Hepatitis C virus Epitope DNA vaccine;───丙型肝炎病毒;表位;DNA疫苗;

59 、The Importance of Helper T-cell Epitope in Vaccine Development───T輔助細(xì)胞在疫苗研制中的作用

60 、Keywords Trichinella spiralis;ES antigen;secondary structure;B cell epitope;───關(guān)鍵詞旋毛蟲(chóng);ES抗原;二級(jí)結(jié)構(gòu);B細(xì)胞表位;

61 、Keywords hepatitis E virus;recombinant protein;monoclonal antibody;antigenic epitope;───關(guān)鍵詞戊型肝炎病毒;重組蛋白;單克隆抗體;抗原表位;

62 、Keywords E. coli Inserted sequence Homology Epitope mimesis;───大腸桿菌;**入序列;基因同源性;抗原決定簇模擬;

63 、Keywords Hantaan virus;Phage display peptide library;Neutralizing antibody;Epitope;───關(guān)鍵詞漢灘病毒;噬菌體展示肽文庫(kù);中和抗體;表位;

64 、Keywords Hepatitis C virus （HCV）;epitope;Genetic immunization;Recombinant BCG;Vaccine;Immune Response;───丙型肝炎病毒（HCV）;表位;基因免疫;重組BCG;疫苗;免疫應(yīng)答;

65 、The method based on expressed peptide for mapping epitope on viral protein was reliable and applicable.───實(shí)驗(yàn)表明，有基因工程表達(dá)的多肽篩選抗原表位的方法是可行的。

66 、Monoclonal antibody 3F3 against conformational epitope of Torpedo acetylcholinesterase───單克隆抗體3F3識(shí)別電鰩**膽堿酯酶構(gòu)象抗原決定簇(英文)

67 、Keywords NMDA receptor;Excitotoxicity;Prokaryotic expression;Epitope;Autoimmune;Neuroprotection;───NMDA受體;興奮毒性;原核表達(dá);表位;自身免疫;神經(jīng)保護(hù);

68 、Keywords hypervariable region 1 of hepatitis C virus;mimic epitope;DNA immunization;cross-reaction;───丙型肝炎病毒高變區(qū)1;模擬表位;基因免疫;交叉反應(yīng);

69 、Phage display random library and its apply in epitope research───噬菌體展示隨機(jī)肽庫(kù)及其在抗原表位研究上的應(yīng)用

70 、To further inestigate the role of capsaicin on the immune system, the authors challenged mice with a colon cancer cell line, which has a well-defined cytotoxic T-cell (CTL) epitope.───為了研究辣椒素在免疫系統(tǒng)中的作用，研究人員在一種結(jié)腸癌細(xì)胞系種植小鼠上實(shí)驗(yàn)，該細(xì)胞系具有明顯細(xì)胞毒性T細(xì)胞(CTL)抗原決定簇。

71 、Antigenic Peptide-independent Phenomena of the Epitope Recognized by Allogeneic CTL───同種CTL識(shí)別表位的抗原肽非依賴(lài)性現(xiàn)象

72 、Keywords HBV;HBcAg;preS1 epitope;fusion protein;therapeutic vaccine;───前S1表位;融合蛋白;治療性疫苗;

73 、Epitope mapping for Rhesus D antigen of DEL phenotype───DEL紅細(xì)胞膜D抗原表位分析

74 、The protein DsbA-G1F/M2 induced significant RSV-specific CTL responses, while DsbA-G1 without CTL epitope did not induce detctable CTL responses.───DsbA-G1F/M2誘導(dǎo)了顯著的RSV特異性CTL殺傷活性,而無(wú)CTL表位的DsbA-G1則不能誘導(dǎo)產(chǎn)生CTL反應(yīng);

75 、hepatitis C virus; epitope; eukaryotic expression；transfection───丙型肝炎病毒；表位；真核表達(dá)；轉(zhuǎn)染

76 、Study of Construction and Mechanism of CTL Epitope Peptide-based Microparticles Vaccine Against PHC───PHC CTL表位肽微粒疫苗的構(gòu)建及機(jī)理研究

77 、Keywords Paragonimus westermani;phage peptide library;antigen;mimic epitope;───關(guān)鍵詞衛(wèi)氏并殖吸蟲(chóng);噬菌體肽庫(kù);抗原;模擬表位;

78 、The result of aninal (rabbit) immunization showed that the levels of WH303-specific antibodies clearly demonstrated a WH303 epitope density dependent pattern.───動(dòng)物免疫實(shí)驗(yàn)表明表位在融和蛋白中的免疫原性與其重復(fù)數(shù)有關(guān)。

79 、The Expression of the Coding Sequence for Foot-and-Mouth Disease Virus's Antigen Epitope in Escherichia coli───口蹄疫病毒抗原表位的編碼序列在大腸桿菌中表達(dá)

80 、Keywords Infectious bursal disease virus（IBDV）;Epitope;Analysis;───傳染性法氏囊病病毒（IBDV）;抗原表位;序列分析;

動(dòng)物抗體的形成機(jī)制？

動(dòng)物的抗體形成機(jī)制是通過(guò)病原體來(lái)刺激動(dòng)物體內(nèi)的免疫細(xì)胞和免疫器官，從而產(chǎn)生一種新的細(xì)胞，這種細(xì)胞只針對(duì)于這種病原體起作用，進(jìn)行對(duì)抗，當(dāng)動(dòng)物體再次有這種病原體進(jìn)入體內(nèi)，就會(huì)進(jìn)行抵抗，從而動(dòng)物體就不會(huì)再得這一種病，這種特殊的細(xì)胞就是抗體

動(dòng)物抗體的形成機(jī)制？

抗原（非自己的物質(zhì)）免疫動(dòng)物

→ 激活免疫B細(xì)胞

→ 轉(zhuǎn)化成漿細(xì)胞

→分泌針對(duì)免疫抗原的特異性的抗體

(一)抗原（Antigen, Ag）是指那些能誘導(dǎo)動(dòng)物免疫系統(tǒng)發(fā)生免疫應(yīng)答、產(chǎn)生抗體同時(shí)又能與免疫應(yīng)答產(chǎn)物在體內(nèi)外特異性結(jié)合、發(fā)生免疫反應(yīng)的物質(zhì)。

抗原的反應(yīng)性取決于抗原決定簇（antigenic determinant），或稱(chēng)為表位（epitope）。一個(gè)抗原分子可帶有不同的決定簇，在免疫測(cè)定中，抗原是指能與抗體結(jié)合的物質(zhì)。能在機(jī)體中引起抗體產(chǎn)生的抗原多為分子量大于5000的蛋白質(zhì)，例如乙型肝炎病毒表面抗原（HBsAg）、甲胎蛋白（AFP）等。